Analytical Differentiation Of 1 Alkyl 3 - 3661 Words

Draft 5 Analytical Differentiation of 1-Alkyl-3-acylindoles and 1-Acyl-3-alkylindoles: Isomeric Synthetic Cannabinoids Jack DeRuiter, Forrest T. Smith, Karim Abdel-Hay and C. Randall Clark* Department of Drug Discovery and Development Harrison School of Pharmacy Auburn University Auburn, AL 36849 * Corresponding Author: Professor C. Randall Clark, Ph. D. clarkcr@auburn.edu phone 334-844-8326 fax 334-844-8331 Abstract The 1-alkyl-3-acylindoles and the inverse regioisomeric 1-acyl-3-alkylindoles can be prepared directly from a common set of precursor materials and using similar synthetic strategies. The EI mass spectra for these isomers show a number of unique ions which allow for the differentiation of the 1-alkyl-3-acylindole compounds from the inverse regioisomeric 1-acyl-3-alkylindoles. The base peak at m/z 214 in the 1-n-pentyl-3-benzoylindole represents the M-77 cation fragment resulting from the loss of the phenyl group and this ion is not observed in the inverse isomer. The 1-benzoyl-3-n-pentylindole inverse regioisomer shows a base peak at m/z 105 for the benzoyl cation. Thus, these two base peaks are the result of fragmentation initiated at the carbonyl-oxygen for both isomers. The 1-pentyl-3-benzoylindole is characterized by the strong intensity carbonyl band at 1703 cm-1 while the amide carbonyl appears as a strong band of equal intensity at 1681 cm-1 in the 1-benzoyl-3-pentyl regioisom er. 1. Introduction A number of synthetic cannabinoids includingShow MoreRelatedDifferentiation Of Cyclic Tertiary Amine Cathinone Derivatives4413 Words   |  18 Pages Differentiation of Cyclic Tertiary Amine Cathinone Derivatives by Product Ion Electron Ionization Mass Spectrometry Younis Abiedalla1, 2, Karim Abdel-Hay1, 3, Jack DeRuiter1 and C. Randall Clark1* (1) Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA (2) Department of Medicinal Chemistry, Faculty of Pharmacy, Omar Al-Mukhtar University, El-Beida, Libya (3) Dept. of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, AlexandriaRead MoreEssay The Chemistry and Effects of Benzodiazepines (BZD)2645 Words   |  11 PagesBZD abusers in forensic settings was demonstrated and the most important analytical techniques used for screening and measurement of BZD in forensic laboratory were described. In this project, selected gas chromatography-mass spectrometry (GC-MS) and Liquid Chromatography- Tandem Mass Spectrometry (LC-MS/MS) spectra of diazepam (MS lab, Prof M. Abdel-Hamid) for confirmation and quantitation of diazepam are presented. 1. Introduction: BZD are a group of chemically synthetic compounds that

Organizations Encourage Workforce to Share, Collaborate...

If organizations want to become more innovative and productive by encouraging and rewarding their workforce to share, collaborate and build collective intelligence they must do more than grant permission for people to build relationships and share their experience inside and outside the organization. They must take incentives for this new way of working into their policies, management systems and training programs. As I’ve discussed elsewhere (â€Å"Social Business 101†³), becoming a social business is much more about changing culture than it is about technology or tools. And changing human behavior or organizational habits is among the tallest of orders. Right now, many businesses don’t have the kind of social (business) contract with workers†¦show more content†¦What happens if your main contractor has gone into liquidation? Can you seek redress from the roofer directly? There is no contract between you and the roofer, so you can’t take action for breach of contract. But you may be able to sue for negligence. And you may be able to take action under the Consumer Guarantees Act. To be successful in a claim for negligence you would have to prove that the roofer owed you a duty of care to do the work to a satisfactory standard, which they breached, and as a consequence you suffered some loss (which was not too remote). For example, you may have needed to pay someone else to fix the problems. Whether the subcontractor does owe you a duty of care depends on the facts which will be decided by the Court. Liability of the builder The liability of the builder was discussed in the Courts in the case of Riddell v Porteous (1999). The Riddells built a house hiring a builder, Mr Porteous, under a labour-only contract. The Riddells later sold the house to the Bagleys who discovered rot in the deck due to leaking. It was found that the deck had not been built according to the building permit. The Bagleys sued the Riddells for the expense of fixing the problem. The Riddells sued the builder for breach of his contractual obligation to build the house in compliance with the permit and fit for its intended purpose. The Riddells also sued the council for negligence in not carrying out the final inspection. The Court held that theShow MoreRelatedOrganizational Theory Integrative Term Project: Concepts and Applications8159 Words   |  33 Pagesthe techniques of individual learning to a team learning process, the transfer of these skills and knowledge to the organization level, and the subsequent sustainment of this valuable knowledge base. To better facilitate organizational learning, individuals have to understand how they learn, how their organizational teams learn, and how this knowledge translates into the collective organizational know-how. The authors also explore the four steps in the organizational learning process that willRead MoreSoft Skills: An Essential in the 21st Century Managers Toolkit2864 Words   |  12 Pagesorder to strive. Since the economic crisis, companies are looking for managers who can create more with less. A rise in people with traditional degrees and certificates in the UK (Office for National Statistics, 2013) causes higher supply of workforce with sufficient technical skills, creating a need for companies to distinguish a person s potential input within a workplace via further means. Looking for the right manager to promote effectiveness and productivity in a company during an economic Read MoreEssay on Nervewire: a Case Study of Leadership5576 Words   |  23 Pages(CEO), and Kirk Arnold, Chief Operating Officer (COO) are the key leaders in this company. Their leadership skills, attributes, personalities, and leadership styles are reviewed and compared to leadership theories; their effectiveness within the organization, as well as their effectiveness with customers and business growth is explored. Cultural norms and gender stereotyping and their influence on the leaders of NerveWire are also evaluated and explored. Keywords: Coaching, In-group collectivismRead MoreDissertation Proposal on Managing Diversity of Workforce18916 Words   |  76 PagesIDENTIFYING AND MANAGING DIVERSITY OF WORKFORCE Robert D. Lawsson (MSc) Abstract The objective of this work is to complete a research proposal on the comparison of work values for gaining of knowledge for management of the multi-generation workforce. The specific focus is upon Generation ‘X’ and the Millennium Generation which are the two primary groups comprising the new workforce. Lawsson R.D. - Identifying and Managing Diversity of Workforce 216 Business Intelligence Journal January OBJECTIVE TheRead MoreInformation Systems Today, 5e (Valacich/Schneider)8043 Words   |  33 Pagesblack Centurian card is issued by invitation only to customers who spend more than $250,000 a year on other American Express cards. B) PG acquires the list of parents-to-be and showers them with samples of Pampers and other baby products to capture a share of their future purchases. C) Kambo, a fashion apparel company that deals directly with customers to sell its products, added retailers to its supply chain to cater to its target audience in remote geographic locations. D) OakTeak, a furniture manufacturingRead MoreStudy Guide7621 Words   |  31 Pagesthemselves Googlers, are everything. We hope to recruit many more in the future. We will reward and treat them well.† Larry Page and Sergey Brin, Founders of Google 1. Introduction Managing human resources effectively has become vital to organizations within the modern and fast†paced business environment (Caldwell, Chatman, OReilly,1990). Human Resources specialists are more important in business strategies today where market is dynamic and changeable. 1.1. Objectives of the study Read MoreFundamentals of Hrm263904 Words   |  1056 PagesSUPPORT YOU AND YOUR STUDENTS NEED! 2-Minute Tutorials and all of the resources you your students need to get started www.wileyplus.com/firstday Student support from an experienced student user Ask your local representative for details! Collaborate with your colleagues, find a mentor, attend virtual and live events, and view resources www.WhereFacultyConnect.com Pre-loaded, ready-to-use assignments and presentations www.wiley.com/college/quickstart Technical Support 24/7 FAQs, onlineRead MoreTurning Ineffective Employees and Bosses into Performers: The New World Order13031 Words   |  53 PagesInternational Business and Management Universidad Autonoma de Bucaramanga Doctor_Tiffany@excite.com Doctor_Tiffdany@yahoo.com September, 2002 Abstract: The objectives of this paper is to: (I) examine the underlying issues of poor performers in organizations and to better understand the causal relationship between leadership style and subordinate performance; (ii) to explore the perceptions of how bosses and subordinates mutually influence each other s behavior; and (iii) it is intended to heightenRead MoreAnalysis of Google Hr Strategy8548 Words   |  35 PagesGooglers, are everything. We hope to recruit many more in the future. W e will reward and treat them well.† L arry Page and Sergey Brin, Founders of Google 1 . Introduction M anaging h uman r esources effectively h as b ecome vital to organizations w ithin t he m odern and f ast† paced b usiness environment ( Caldwell, Chatman, OReilly , 1990 ) . H uman Resources specialists are m ore important in business strategies today w here m arket is dynamic and c hangeable . 1 .1. O bjectivesRead MoreChapter Practice13676 Words   |  55 Pagesnations. D. the potential to lower costs of operation even if the primary market is at home. Page 6 31. Units coordinate their activities with headquarters and with one another, units adapt to special circumstances only they face, and the entire organization draws upon relevant corporate resources. These are all attributes of which type of strategy? A. a global strategy B. a transnational strategy C. an international strategy D. a multidomestic strategy 32. Pressures to reduce costs require that A

Energy saving measures Essay Example For Students

Energy saving measures Essay 1.)There are talks going on around the world about the so called ?Global warming? and there is pressure among power industry as well to reduce emissions and to be environment friendly and as a result alternate sources of energy are being looked upon for future energy requirements. ?Even the UPA government signed the nuclear pact with US so that we can have more nuclear power stations as cleaner energy source. ?Various industries in India are going green. Wipro in Mysore has developed a campus which uses solar energy for all its operations. ?One more example I can state is that of Mayor of Mumbai Shradhha Jadhav?s home where all the lights and other electric items in the compound run on solar energy. ?There are also growing number of buildings which are using renewable sources of energy for their daily operationsWhat I feel is what has happened because of social pressure is that countries are trying to incorporate the changes to use renewable and clean energy resources and many companies too within India are trying to build up their image by going green and by showing that they are doing something good for the country. As of now 57 % of total consumption is from coal, which is expected to reduce with more use of renewable energy resources. 2.) With more number of IT jobs, BPO jobs the nature of occupation is changing, these companies have high number of technical equipments and because of this lifestyle change there is a huge increase in demand in power supply. If you calculate the peak deficit in India it?s about 13 % in May ? June. 3.) To meet the demands private players are allowed to enter into Indian markets, because of private companies entering into Indian markets the tariff rate is pretty high. For e.g. Reliance power tariff rate in Mumbai is higher than that of Tata Power. As a result recently in Malad when tata power was allowed to enter the region where consumers were using reliance power, many consumers shifted to tata power because of cheaper tariff rates, previously this wasn?t the case and each area was under one player only, but the scenario is changing now. 4.) Now, the main thing that comes out is to set up new power plants for which one prime important factor is to get the location to set up the plant. There have been protests from the locals to set up new power plants in their areas. E.g. Last year there was a strong opposition from locals in Jaitapur for the set up of nuclear power plants, they refused to accept the cheques in lieu of land. So, these are the challenges which society has imposed upon the power sector companies which have to be dealt with carefully if we are to minimize the peak shortage of electricity in the coming years.

Rauschenberg as a Reflection of Three Philosophers free essay sample

This paper discusses Robert Rauschenbergs painting Persimmon from the concepts presented by Heidegger, Merleau-Ponty and Nietzsche. The author states that Rauschenbergs Persimmon does not look like a real subject, yet it is a real thing. From Heidegger, the strife between the rational and the irrational is the key to art. From Merleau-Ponty, the strength of Rauschenbergs work is found in its inherent irrationality. From Nietzsche, art represents the strife inherent in human condition. Rauschenberg frequently takes subjects from nature (again, as is traditional in Asian art) and reconfigures them in a bright, compiled, collage-style form, so that the apparently surface perceptions of nature and color become slightly askew. One is cognizant of the fact that one is observing something simple and natural but not necessarily observing the subject as one might in so-called real life and in nature. One feels as if one is viewing the artists perceptions of what is real, rather than the thing itself. We will write a custom essay sample on Rauschenberg as a Reflection of Three Philosophers or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page